Here are my week 10 NFL picks. 49ers vs. Giants: 49ers. The Giants allow an average of 127.1 yards rushing per game. So, I’m setting the over/under for Gore’s rushing total at 160 yards. I’m also setting Brandon Jacobs over/under at 30 rush yards. It’s tough for any team to win when you can’t run or stop the run, so the Giants are going to lose. Score prediction: 27-20 Niners….